According to Dr. Sheila Crowe, M.D., a professor of medicine and director of research at University of California, San Diego School of Medicine, having the genes HLA DQ2 and DQ8 puts you at higher risk of celiac disease, but they don't confirm a diagnosis. 95% of the people with CD have the gene HLA DQ2 and 5% of those with CD have the gene DQ8.
If you have the genes for celiac disease, it’s important for you to be further tested with an antibody blood test panel and biopsy. If left untreated, celiac disease can lead to other complications such as infertility, osteoporosis, type 1 diabetes, thyroid problems, autoimmune disease and intestinal cancer. It is also important to have these tests before cutting out gluten from your diet.