Which tests are currently being used to screen for celiac disease?

The gold standard for medical diagnosis (and for health insurance purposes) is the following blood antibody test panel  and intestinal biopsy. 

  • Anti-endomysial antibodies (EMA) - IgA
  • Anti-tissue transglutaminase antibodies (tTG) - IgA
  • Total IgA level

An endoscopic biopsy of the small intestine is typically a 10-minute procedure performed under sedation.  The doctor inserts a tube into your mouth, through your stomach and into your small intestine (duodenum) where small tissue samples are obtained.  It’s important to obtain at least 4 or more samples from different parts of the duodenum, including the duodenal bulb, to yield the highest diagnostic value, and have the samples interpreted by an experienced pathologist. 

For more extensive information on testing methods, including genetic testing, see Testing for Celiac Disease.